OECD GUIDELINE FOR TESTING OF CHEMICALS Proposal for a New DRAFT GUIDELINE 434: Acute Dermal Toxicity – Fixed Dose Procedure
ثبت نشده
چکیده
1. OECD Guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress and animal welfare considerations. The original acute Dermal Toxicity Guideline TG 402 (1) was adopted in 1987. Development of a dermal Fixed Dose Procedure (FDP) was considered appropriate, following adoption of the revised Oral FDP, OECD Guideline 420 (2) and deletion of OECD Guideline 401 in December 2001. This FDP guideline will allow the use of a series of fixed doses for the determination of acute dermal toxicity in only one sex (usually females).
منابع مشابه
OECD GUIDELINE FOR THE TESTING OF CHEMICALS Acute Oral Toxicity: Up-and-Down Procedure
1. The proposal for this guideline was submitted by the United States. The concept of the upand-down testing approach was first described by Dixon and Mood (1)(2). In 1985, Bruce proposed to use an up-and-down procedure (UDP) for the determination of acute toxicity of chemicals (3). There exist several variations of the up-and-down experimental design for estimating an LD50. This guideline is b...
متن کاملOecd Guideline for the Testing of Chemicals
1. In Copenhagen in June 1995, an OECD Working Group on Reproduction and Developmental Toxicity discussed the need to update existing OECD Test Guidelines for reproduction and developmental toxicity and the development of new Guidelines for endpoints not yet covered. The Working Group recommended that the Guideline for Developmental Toxicity should be revised, based on a proposal received from ...
متن کاملOECD GUIDELINE FOR THE TESTING OF CHEMICALS DRAFT PROPOSAL FOR A NEW TEST GUIDELINE In Vitro Skin Sensitisation: U937 Cell Line Activation Test (U-SENSTM)
1. A skin sensitiser refers to a substance that will lead to an allergic response following a secondary skin contact as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS) (1). This Test Guideline (TG) describes the in vitro procedure called U937 cell line activation Test (U-SENSTM), to be used for supporting the discrimination between ...
متن کاملOecd Guideline for Testing of Chemicals
1. OECD guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress or changing assessment practices. The concept of the up-and-down testing approach was first described by Dixon and Mood (1)(2)(3)(4). In 1985, Bruce proposed to use an up-and-down procedure (UDP) for the determination of acute toxicity of chemicals (5). There exist several variations of...
متن کاملOecd Guidelines for the Testing of Chemicals
1. OECD guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress or changing assessment practices. The concept of the up-and-down testing approach was first described by Dixon and Mood (1)(2)(3)(4). In 1985, Bruce proposed to use an up-and-down procedure (UDP) for the determination of acute toxicity of chemicals (5). There exist several variations of...
متن کامل